刘威副研究员简介
刘威,男,1985年出生,中共党员,博士,副研究员,硕士研究生导师,约翰斯•霍普金斯大学访问学者。农业农村部畜禽细菌病防治制剂创制重点实验室、湖北省自然科学基金计划创新群体核心成员。先后主持、承担了国家自然科学基金、科技部重点研发计划项目子课题等国家、省部级项目7项。获国家一类新兽药注册证书1件;湖北省科技进步二等奖1项;授权国家发明专利11件;在Vaccines、Frontiers in Cellular and Infection Microbiology、Journal of Bacteriology、BMC Genomics、Microbial Pathogenesis、PLoS One 等SCI期刊发表论文21篇,在中国兽医学报、动物医学进展等期刊发表学术论文30余篇。
研究方向:
1. 支原体、衣原体、致脑膜炎性大肠杆菌等病原与宿主的相互作用及其免疫逃逸的分子机制研究;
2. 动物疫病快速诊断试剂研发;
3. 细菌基因工程疫苗的分子设计与创制。
代表性成果:
1. Wei Liu; Peizhao Jiang; Tao Song……et al; A Recombinant Chimera Vaccine Composed of LTB and Mycoplasma hyopneumoniae Antigens P97R1, mhp390 and P46 Elicits Cellular Immunologic Response in Mice, Vaccines, 2023, 11, 1291.
2. Wei Liu; Pengcheng Jiang; Keli Yang……et al; Mycoplasma hyopneumoniae Infection Activates the NOD1 Signaling Pathway to Modulate Inflammation. Frontiers in Cellular and Infection Microbiology, 2022, 12:927840.
3. Wei Liu; Danna Zhou; Fangyan Yuan……et al; Surface proteins mhp390 (P68) contributes to cilium adherence and mediates inflammation and apoptosis in Mycoplasma hyopneumoniae, Microbial Pathogenesis, 2019, 126: 92-100.
4. Wei Liu; Shaobo Xiao; Mao Li……et al; Comparative genomic analyses of Mycoplasma hyopneumoniae pathogenic 168 strain and its high-passaged attenuated strain, BMC Genomics, 2013, 14(80): 1-13.
5. Wei Liu; Liurong Fang; Mao Li……et al; Comparative genomics of Mycoplasma: analysis of conserved essential genes and diversity of the pan-genome, PLoS One, 2012, 7(4): e35698.
6. Wei Liu; Zhixin Feng; Liurong Fang……et al; Complete genome sequence of Mycoplasma hyopneumoniae strain 168, Journal of Bacteriology, 2011, 193(4): 1016-1017.
7. Wei Liu; Liurong Fang; Sha Li……et al; Complete Genome Sequence of Mycoplasma hyorhinis Strain HUB-1, Journal of Bacteriology, 2010, 192(21): 5844-5845.
在研项目:
1、企业横向课题:畜用细菌与支原体培养基开发与研究,2022.12-2027.12,75万元,主持。
2、湖北省预防兽医学重点实验室开放课题:膜脂蛋白 mhp390 在猪肺炎支原体感染与致病中的作用研究,2023.01-2024.12,5万元,主持。
联系方式:电话:15527793518
邮箱:liuwei@hbaas.com